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Hypotheses 55 GaliR

Early-phase human studies (including data in healthy older adults) have been conducted, but robust clinical evidence supporting its use in confirmed GH deficiency or any other licensed indication is lacking

By adhering to these standards, we can maximize the therapeutic potential of peptides while minimizing risks

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Therefore, we found that the enhanced insulinotropic effect of exendin-phe1 in vitro is recapitulated in a mouse model of T2D, suggesting that GLP-1R trafficking plays a role in determining the responses to therapeutic GLP-1R agonists in vivo