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Advanced / Aggressive Protocol (1 mL = ~10.0 mg/mL) Note: The 12 mg dose represents the highest dose tested in Phase 2 trials [3] [4] , producing maximum weight-loss efficacy (~24% body weight at 48 weeks)
They both come in six different doses, with new patients starting on the lowest dose and gradually working their way up, and have similar potential side effects, which tend to be mild gastrointestinal issues.
To address this, polyagonist therapeutics that simultaneously activate multiple receptors are hypothesised to offer more balanced glycemic and metabolic regulation pathways, presenting a distinct molecular strategy compared to currently available mono- and dual-receptor agonists [15]
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