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The catalytic site resides in the C-terminal region of the extracellular part of the protein, but the extracellular domain also contains a cysteine-rich region and a region rich in glycosylation sites

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Adherence continues to decline in year two, particularly among individuals using GLP-1s for weight management rather than diabetes

Mechanical stress can unfold or aggregate these structures

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Safety Evidence : Does the paper report adverse events, discontinuation, tolerability, or safety concerns