PIONEER 3 PIONEER 3 compared the efficacy and safety of the addition of oral semaglutide or the DPP-4 inhibitor sitagliptin as add-on therapy in patients with T2DM receiving metformin with or without a sulfonylurea
But combining peptides can increase the chance of side effects like higher cortisol and prolactin
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Best fit: Determined by A1C, insurance, side effect tolerance, and physician evaluation
If you experience any intolerable side effects such as nausea, vomiting, or dizziness when increasing your dose, it may be a sign that you need to slow down the dose increase or revert to a previous dose that worked for you
Finally, the patent protection they hold allows them to set the market price without immediate competition