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Trends Mol Med (2018) 24:45871

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This can lead to several changes in the cellular activity, including regulation of gene expression, reduction in the release of transmitter, and inhibition of long-term potentiation

The biomarkers which had the effect sizes that were significant comprised of 28 biomarkers which are in descending order of the effect size given as: CTPN (SMD 37.93, p = 0.03), TG (SMD 16.60, p = 0.0007), BG (SMD 7.54, p = 0.00001), TC (SMD 7.38, p = 0.009), HDL (SMD -5.84, p= 0.0002), LDH (SMD 5.66, p = 0.0005), IL-6 (SMD 5.49, p = 0.00001), AGEs (SMD 5.43, p = 0.004), MDA (SMD 4.78, p = 0.00001), HW (SMD 4.73, p = 0.05), GSH (SMD -4.60, p = 0.009), IL-1 (SMD 4.44, p = 0.003), EF% (SMD -4.13, p = 0.00001), CC3 (SMD 3.91, p = 0.002), NLRP3 (SMD 3.59, p= 0.03), CK-MB (SMD 3.28, p = 0.004), FB% (SMD 3.25, p = 0.01), NF-KB (SMD 3.13, p = 0.0001), HMGB1 (SMD 3.00, p = 0.0001), FS% (SMD -2.91, p= 0.00001), COL III (SMD 2.43, p = 0.01), TLR4 (SMD 2.38, p = 0.009), HW/BW (SMD 2.31, p = 0.007), pJNK (SMD 1.87, p = 0.0001), BW (SMD -1.74, p= 0.05), LVIDs (SMD 1.64, p = 0.04), TGF-1 (SMD 1.50, p = 0.05), and TNF-A (SMD 1.11, p = 0.03)

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