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In rare cases, a person can react to the injection solution

[2] Estradiol cypionate injection is compounded on an individualized basis by 503A pharmacies pursuant to a patient-specific prescription and may also be produced in cGMP-compliant batches by 503B outsourcing facilities for office use, allowing clinicians flexible access to bioidentical estrogen preparations while maintaining regulatory oversight of quality and sterility

Faridi MH, Khan SQ, Zhao W, et al

On May 5, one of those nominators clarified that the withdrawal was meant to apply only to the injectable route

The placebo effect is a big part of why people think HCG works