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Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity
In these antioxidant reactions, glutathione is oxidized to form the oxidized disulfide form, GSSG which is then, in turn, reduced back to glutathione using NADPH.[ref] Mitochondria are essential for the production of ATP for energy storage in cells
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It is reported that the hyperacetylation modification of mitochondrial proteins caused by the imbalance of NAD + redox mainly promotes the pathological remodeling of the heart through two different mechanisms
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