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This occurs because body fat produces estrogen, and losing it quickly can temporarily disrupt hormone balance
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doi:10.1002/oby.24336 Barana, L., De Fano, M., Cavallo, M., Manco, M., Prete, D., Fanelli, C
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The Most Common Digestive Side Effects Almost half of patients on GLP-1 medications experience digestive symptoms, especially when they first start or when their dose gets increased
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