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Rotate sites: Each injection should go to a different location on the abdomen to avoid lipohypertrophy
The mechanism of these changes will however require further research
A 48-week Phase 2 trial reported in The Lancet in 2025 showed mean weight reduction ranging from approximately 9% at the lowest dose to 20% at the highest dose, compared with 0.4% on placebo
Patients with elevated fasting insulin, insulin resistance (HOMA-IR above 2.5), or inflammatory markers like elevated hsCRP may show different GLP-1 response patterns than those with preserved insulin sensitivity
Dosing should be individualized based on patient response and laboratory markers
The official reason given is safety, even though these peptides have been used safely for years and are produced by reputable compounding pharmacies
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