The gut produces it whenever we eat
Type 2 diabetes mellitus (DM2) affects a 13.8% of the Spanish population1 and its prevalence is expected to increase in the future.2 The presence of DM2 increases significantly the risk of cardiovascular events, chronic kidney disease (CKD), and premature death3,4 and as its prevalence increases it is expected to rise the incidence of microvascular and macrovascular complications.5 Until the last decade, the control of blood glucose, blood pressure, dyslipidemia, and the use of inhibitors of the renin-angiotensin system (iSRA) have been the only strategies available to reduce cardiovascular and renal risk in this population
Best practice is up to 28 days post-puncture when refrigerated at 28 C and handled with strict aseptic technique
Cotadutide also led to 2.1 kg body weight loss relative to placebo
SURMOUNT-3 (N=579), which enrolled patients who had already completed a 12-week intensive lifestyle run-in, showed 18.4% additional weight loss with tirzepatide on top of lifestyle modification [23]
How long does it take for GLP-1 RAs (Semaglutide & Tirzepatide) to work