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Both are: Highly effective for weight loss Well-tolerated by most people Significantly better than non-medication weight loss approaches Improving health outcomes for millions of patients The small difference in outcomes (7.6% on average) matters less than: Choosing a medication you can take consistently Affording treatment long-term Working with a supportive provider Maintaining lifestyle changes alongside medication Frequently Asked Questions Which is stronger, semaglutide or tirzepatide

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The effect builds with titration, and many patients notice meaningful appetite reduction within the first two weeks