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At the epigenetic level, decreasing NAD + /NADH ratio with age inhibits SIRT1/3 activity and impairs PGC-1-mediated mitochondrial biosynthesis and antioxidant gene expression [292, 293]
Naseer et al
These include thoughtful anesthesia planning, careful monitoring of heart and lung function, and, in select cases, the use of ultrasound to check stomach contents before surgery
doi: 10.1002/cam4.3345 165 MukamaTSrourBJohnsonTKatzkeVKaaksR
The contraindications are due to health concerns
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