Regular injections ensure that levels remain stable, whereas infrequent injections may result in declining B12 levels over time
The consistency of the safety profile across short-term and long-term trials suggests that AOD-9604 does not produce cumulative toxicity or delayed adverse effects that emerge only with chronic administration
Vitamin B12 is absorbed in our body with the help of a protein produced in your stomach called the intrinsic factor
For others, with milder or temporary deficiencies, the initial shots might lead to longer periods of feeling well, potentially even allowing for a switch to oral supplements under strict medical guidance
However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007
In contrast, in the obese ob/ob mice, both AOD9604 and hGH caused a pronounced decrease in body weight