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The current KDIGO guidelines do not recommend SGLT2i for people in more advanced stages of CKD (eGFR 300 mg/g) and reduced progression of UACR in people with macroalbuminuria when compared with placebo

5 These researchers indicate that when patients are unable to tolerate paroxetine or venlafaxine or fail a trial of therapy with these agents, desvenlafaxine, sertraline, fluoxetine, and citalopram should be considered as second- or third-line options

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These enzymes except CBL possess a -lyase step in the catalytic mechanism in common

Ma X, Zhang Y, Jiang D, Yang Y, Wu G, Wu Z