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Perkin Elmer, FP1489) were then added for 10 min at room temperature

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statistical significance was inferred if the 95% CI of log ( / K A ) estimate did not cross zero

Preclinical studies with SAR425899 clearly demonstrated dual receptor agonism in vitro and in preclinical in vivo studies, with a higher potency for the GLP1R than for the glucagon receptor in order to counterbalance the GCGR mediated increase of blood glucose levels through GLP-1 agonism 11,12,13

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IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice