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Standard dosing: 1-2 mg per injection, once or twice weekly
In the nucleus, HMGB1 can interact with DNA and histones to maintain chromosome structure and function, while, in the cytoplasm, HMGB1 can combine with Beclin 1 protein to promote autophagy
This is explained by a shift in receptor subtype-specificity toward enhanced activation of CC-motif-chemokin-receptor 5 (CCR5) (89)
Existing 1 H-MRS studies are small and show some conflicting results, with different studies focusing on different regions of the brain
doi: 10.1016/j.brainres.2015.12.052 164 QiLKeLLiuXLiaoLKeSLiuXet al
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