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(2015) 101:1320S9S

3.6.3.2 Microbial metabolites A substantial body of research highlights the role of gut microbiota and their metabolites, particularly SCFAs, in regulating metabolic, endocrine, and immune functions, with emerging evidence pointing to their involvement in neuro-immunoendocrine pathways through the MGBA (Silva et al., 2020)

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While specific therapies for IBM are still lacking, NAD + boosters have shown promising results in various models, including nematodes with amyloid aggregation, aged rodents, and human muscle cells from IBM patients

As such, researchers in the nascent field of regenerative medicine have begun to study alternative ED treatments that consider the roles of angiogenesis, vascular insufficiency, and endothelial dysfunction in the disease