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Given the reabsorption of renin by proximal tubule cells through megalin, and the broad expression of ACE within the kidney, allowing locally synthetized ANG II independent action, the interference of SGLT-2-i with intrarenal RAS could explain such results
Eating less than you need to maintain your weight forces your body to call upon stored fat reserves to make up the difference
They are tools that work at the margins, and the margins still depend on training and nutrition doing the heavy lifting
Over time, this leads to steady, sustainable weight loss
Mild and temporary reactions may occur in some cases
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