To overcome ICB resistance, combinations of decitabine or azacitidine with pembrolizumab are being tested in refractory Hodgkins lymphoma and solid tumors (NCT05355051, NCT03445858)

Acronyms A1C - Hemoglobin A1C ADA - American Diabetes Association CVD - Cardiovascular disease DM - Diabetes mellitus FBS - Fasting blood sugar GFR - Glomerular filtration rate GI - Gastrointestinal GLP-1 - Glucagon-like peptide-1 OSA - Obstructive sleep apnea RCT - Randomized controlled trial T2DM - Type 2 diabetes mellitus Thyroid C-cell tumor = Thyroid medullary tumor DRUGS IN CLASS Dual GLP-1 and GIP agonists Tirzepatide (Mounjaro) - marketed for diabetes Tirzepatide (Zepbound) - marketed for weight loss MECHANISM OF ACTION GLP-1 and GIP GLP-1 stands for "glucagon-like peptide-1," and GIP stands for "glucose-dependent insulinotropic polypeptide." GIP is also sometimes referred to as "gastric inhibitory polypeptide." GLP-1 and GIP are hormones secreted by specialized cells in the small intestine in response to food consumption
Lin S-H, Yang T-R, Chuang IC, et al
For older adults (55+): Lower starting doses of 100-200 mcg are often recommended, with gradual increases as tolerated
This scientifically designed titration process is crucial for minimizing common gastrointestinal side effects (like nausea, diarrhea, vomiting, constipation) and enhancing adherence, which is vital for achieving the medications full clinically proven benefits over time
Yes, if it suits your skin type and is gentle