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In vivo studies, such as that by Morris et al., used a preclinical model of a high-fat diet in infant rats to mimic insulin resistance, identifying impaired nigrostriatal dopamine function as a consequencea hallmark of PD neuropathology [152]

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Many platforms provide reality checks and cooling-off options

2.2 Data Extraction and Study Selection The databases were scanned by one author (TDC) and selected data were independently extracted by two authors (TDC, BC)

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