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When lacking or depletion of GSH, it may cause producing toxic effects or increasing the toxic effects of many chemicals or environmental factors

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When it binds the melanocortin-1 receptor on melanocytes it raises intracellular cyclic AMP, which switches the pigment machinery toward producing eumelanin the darker, more photoprotective form of melanin without needing UV light as the trigger [2]

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no standard dose reduction is required