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120,121,122,123,124 Mitochondrial integrated stress response The mt-ISR in mammals is a multifaceted mechanism that includes a transcriptional response, metabolic remodeling, and the mitochondrial unfolded protein response (mt-UPR)
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Underlying metabolic conditions Is obesity, type 2 diabetes, or metabolic syndrome present and adequately managed
Additional assessment of body weight change or self-measured plasma glucose, along with the analysis of each change in fasting and postprandial glucose, would be clinically beneficial
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