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Combination studies with semaglutide consistently outperformed the GLP-1 drug on its own, which is the cleanest available evidence that an amylin analog adds to, rather than duplicates, incretin-based weight loss
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Key takeaways GLP-1 medications do not inherently cause muscle wasting. Most weight lost on semaglutide or tirzepatide is fat , not muscle. Some lean-mass loss during weight loss reflects adaptive remodeling , not pathology. Adequate protein intake and resistance training significantly reduce muscle loss during GLP-1 therapy. Do GLP-1 Medications Cause Muscle Wasting
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