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People with certain medical conditions, abnormal lab results, cancer history, uncontrolled diabetes, pregnancy, or active endocrine disorders should be evaluated carefully before treatment
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However, pGSN interferes with this process by inducing apoptosis in M1 macrophages and reducing their production of NO and TNF, thereby inhibiting their anti-tumor function
In addition to stability and delivery challenges, peptides, particularly those derived from non-human sources, carry the risk of triggering immune responses
Table 1 shows representative clinical trials and results of GLP-1RAs in liver diseases
Nagayama K, Kyotani Y, Zhao J, Ito S, Ozawa K, Bolstad FA, Yoshizumi M
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