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A Phase 2 clinical trial published in the New England Journal of Medicine (2023) demonstrated participants receiving retatrutide achieved up to 24.2% mean weight reduction over 48 weeks the highest reduction reported for any investigational compound in its class at that time

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These medications may affect the way the brain responds to dopamine signals in these areas, decreasing the overactive reward response that drives impulsivity and cravings for substances, she told Healthline

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the KYDN neurons and then GnRH-secreting neurons) (25), the positive improvement of the metabolic impairment is probably not the only one needed to re-activate a normal reproductive profile, given that no significant changes in plasma LH concentrations were observed during the 6 months of treatment

Z., Chachra, S