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4-10 These benefits exceed those of other second-line medications such as dipeptidyl peptidase-4 inhibitors or sulphonylureas, as demonstrated in active-comparator trials and meta-analyses of RCTs 11-18 and real-world observational studies

Individuals with pre-existing conditions such as chronic kidney disease , type 1 diabetes , or inflammatory bowel disease should exercise particular caution, as dehydration and electrolyte disturbances can have more serious consequences in these groups

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This can result from: For some, this fatigue feels similar to early diabetic fatigue, which emphasizes the need to monitor metabolic markers closely

Rigid adherence to exact macronutrient targets creates an unhealthy relationship with food

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