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Their activation near the blood-brain barrier, in the perivascular space, can increase vascular permeability and prime microglia, the resident immune cells of the central nervous system 21
Phillips, D
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Glutathione depletion and oxidative stress
Among those who stayed on treatment for the full 68 weeks, cagrilintide 2.4 mg delivered an average of about 12% body weight reduction , compared to 2.3% for placebo
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