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Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus

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552 Taking 2,000 mg curcumin daily for 12 weeks was found to increase NO availability and reduce arterial stiffness in a placebo-controlled trial in 39 healthy middle-aged and older adults

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The peptide has been observed to mediate action by eliminating free radicals (charged molecules that damage tissue)