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Seek immediate emergency care for suicidal thoughts, severe panic attacks with chest pain, or any thoughts of self-harm

Pregnancy and breastfeeding increase B12 requirements, and pregnant women with B12 deficiency may need more frequent monitoring and potentially adjusted treatment schedules

Intramyocellular lipid deposition, common in obesity but also a feature of sarcopenia, may result in part from mitochondrial dysfunction with resultant accumulation of unmetabolised free fatty acids [53]

Figure 1 In the emulated target trial, treatment strategies were defined as initiation of a GLP-1 RA or initiation of a DPP-4i at baseline

The popularity of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) has increased in recent years (Rodriguez et al., 2023)

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