Clinical studies show that stopping GLP-1 therapy often leads to weight regain (STEP 4 trial on semaglutide withdrawal), so its important to understand the long-term plan
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Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F
For example, dulaglutide (Trulicity) is only authorised for type 2 diabetes, while semaglutide 2.4mg (Wegovy) and liraglutide 3mg (Saxenda) have specific authorisations for weight management with eligibility criteria defined by NICE guidance
Because cancer cells hijack the protective capability of NRF2 to promote drug resistance and proliferation, specific NRF2 inhibitors would be desirable for the treatment of cancers that have constitutively active NRF2
10.1074/jbc.M208704200 41