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The budget office estimated about $35 billion in increased net costs from 2026 to 2034, noting healthier Medicare members would not offset the overall costs

Presented at: American Diabetes Association Scientific Sessions

The incidence of pancreatitis was numerically higher among those on a GLP-1 RA (2.7% placebo, 1.2% OCA 10 mg, 1.3% OCA 25 mg) compared with the overall safety population (0.8% placebo, 0.6% OCA 10 mg, 1.0% OCA 25 mg)

[3] [5] For patients with LDL-C 190 mg/dL, high-intensity statins are first-line therapy, with consideration of ezetimibe, bempedoic acid, or PCSK9 inhibitors for additional lowering

Solution: Complete full 4-8 week protocol even when pain subsides

This creates a two-tier system: GH is the pulsatile, short-lived messenger