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However, we found that both Alanine and Cystine substantially fell outside of healthy reference ranges, with Cystine being dramatically reduced in both affected and unaffected siblings with average plasma concentrations of 3.0 mol/L and 3.3 mol/L respectively, while Alanine was found to be elevated regardless of disease status (U:595.5 mol/L, K:589.0 mol/L)

Acknowledgements IAP acknowledges financial support from Empirikeion Foundation

Taking two doses in the same week to "catch up" dramatically increases nausea and vomiting risk

Nausea Nausea is the most common side effect

Adding a second weight-loss agent is suggested to enhance the effect, but the optimal order and schedule for step therapy are not known

Lembke says