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Take, for example, the digestive enzyme nicotinamide N-methyltransferase (NNMT), which converts NAM to methylnicotinamide.32 Methylnicotinamide, for its part, can lead to mitochondrial dysfunction, in turn contributing to the pathogenesis of insulin resistance, coronary artery disease, and Parkinsons 24 effectively, the opposite of what youd want from your NAD+ boosting efforts

In contrast, semaglutide, alongside similar weight loss drugs like Zepbound (tirzepatide), have gone through extensive reviews and are FDA-approved

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S2), this trend did not rise to the level of statistical significance