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An association between ROS levels and IFN- response in HIV-1 infection has been reported, whereby HIV-1 reverse transcriptase enzyme-induced increased ROS levels induce stronger IFN- responses 115
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These studies provide researchers with controlled environments for examining biological mechanisms before broader scientific conclusions are drawn
Ultimately, 14 RCTs 10,11,1526 and one open-label clinical trial 12 met the inclusion criteria
Thus, by contradiction, the survivors at high temperatures are not heat-tolerant mutants or persistor-like cells
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