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Biomed Pharmacother (2018) 106:130716

This dysfunction compromises cellular energy metabolism, increases oxidative stress, and triggers apoptotic cascades

We've gone so far in avoiding the elephant in the room that we've normalised it." Obesity, doctors warn, is a gateway to a host of diseases

Studies in aged rats show that mitochondrial membrane potential, cardiolipin content, respiratory control ratio, and cellular oxygen uptake are significantly reduced compared to young animals, while oxidative stress markers are elevated

Some people experience mild nausea that resolves within days, while others report more persistent digestive changes during the first few weeks of therapy