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Lipid accumulation is ahead of epithelial-to-mesenchymal transition and therapeutic intervention by acetyl-CoA carboxylase 2 silence in diabetic nephropathy
10.1523/ENEURO.0443-18.2019 6 BouhlalS.EllefsenK
Reid, 1998
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The signaling molecules Akt, Ras, and AMPK can induce lactate production by activating glycolysis to cause the Warburg effect, prompting tumor cells to meet energy demand through Gln metabolism
Specifically, rodent studies showed an increased incidence of thyroid C-cell tumours (medullary thyroid carcinoma) when exposed to GLP-1 receptor agonists at doses significantly higher than those used therapeutically in humans
