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Overall, Trp metabolism influences the functional spectrum of macrophages through two intertwined pathways, namely the stress response induced by Trp depletion and the AhR signaling mediated by Kyn/indole derivatives. The overall outcome is often manifested as restriction of pro-inflammatory programs and support of immunoregulatory/tolerance-related phenotypes, although this effect is condition-dependent and influenced by ligand source (host or microbial), inflammatory stage, and the tissue microenvironment

Wegovy (semaglutide) is a breakthrough medication for chronic weight management, approved for adults with obesity or overweight conditions accompanied by weight-related health issues

Further, targeted metabolomics results revealed that GGCT knockdown markedly attenuated TCA cycle flux, decreasing key intermediates including pyruvate, succinate and fumarate (Fig

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It functions similarly to semaglutide by stimulating insulin release and decreasing appetite

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