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It targets the disc extracellular matrix directly and may help maintain structural integrity before significant herniation occurs

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The synthesis and characterization of compounds 112 and PRP are given in Supplementary Methods, Supplementary Figs

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At 0.5mm, a stamped microneedle traverses the stratum corneum (typically 10 to 30 microns), passes through the viable epidermis (50 to 100 microns), and lands in the upper papillary dermis (which begins around 100 to 150 microns deep)

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