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Accordingly, the World Health Organization classifies G6PD-d based on the level of residual G6PD activity, with severe deficiency (Class I) causing chronic nonspherocytic hemolytic anemia and the least severe deficiency (Class IV) with little-to-no appreciable phenotype 8,11

The absence of published bioavailability studies, coupled with theoretical limitations, suggests that berberine patches are unlikely to deliver therapeutically relevant amounts of the compound into systemic circulation