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Further, this trend was similarly observed in three distinct genetic subsets: in only protein-coding genes (18,713 genes) ( Figure 1e ), in the highest variable genes (2,000 genes) ( Figure 1f ), and in a set of previously identified (31) pan-immune-related genes (2,565 genes) ( Figure 1g )
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The 4mg dose produced an average weight loss of 17.1% at 48 weeks in the clinical trial
The 12 mg group saw a 4.5-point drop on the WOMAC pain scale (a 75.8% reduction), and roughly 1 in 8 participants on retatrutide became completely free of knee pain, compared with 1 in 24 on placebo
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