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The pathophysiology of DN is complex and multifactorial, involving metabolic, vascular, and inflammatory mechanisms that converge to damage peripheral nerves

You then take it through what we call the preclinical stage, which means we test in every different way we can possibly do to see whether it would a) induce protection, but b) also that it wouldn't cause side effects

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Guo J, Huang X, Dou L, Yan M, Shen T, Tang W, Li J (2022) Aging and aging-related diseases: from molecular mechanisms to interventions and treatments