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Another recent screening identified that H3K9 demethylation-mediated upregulation of BCAT1 and subsequent BCAA metabolic reprogramming is able to enhance the capacity for sublethal epidermal growth factor receptor (EGFR) inhibitor (TKI) resistance by producing ROS scavengers in lung cancer, which is a cancer where EGFR mutations are commonly found (Wang et al., 2019b)
Rosenkilde, MM (July 2021) 'The role of incretins on insulin function and glucose homeostasis', Endocrinology , 162/7, bqab065
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The molecule must survive digestion, cross biological membranes, avoid liver metabolism, and arrive at GIP and GLP-1 receptors in sufficient concentration
PMID: 10540137 Braganza J.M
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