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The early secretion of GLP-1 might involve an indirect neural or hormonal mechanism (91)
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However, panellists also agreed that, in the absence of evidence and clear, consistent guidance, there is a need for an expert-endorsed treatment algorithm, to support clinical decision-making for adults with CKD and T2D
In SUSTAIN-6, use of once-weekly semaglutide led to an increased risk of diabetic retinopathy worsening (HR 176, 95% CI 111 276) [1], and it has been speculated that this can likely be attributed to early worsening given the rapid improvement in glycemic control in the semaglutide arm [21]
doi:10.1093/hmg/ddg124 Aoki, J., Inoue, A., Makide, K., Saiki, N
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