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To assess this, randomized trials typically evaluate the primary outcome of major adverse cardiovascular events (MACE), which includes cardiovascular death, non-fatal stroke, and non-fatal myocardial infarction (MI)

Blood pressure medications, diuretics, and SGLT2 inhibitors may require dose adjustment as weight loss and improved insulin sensitivity occur

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GLP-1 Side Effects at a Glance Nausea & vomiting Constipation Diarrhea Reflux & sulfur burps Loss of muscle and lean mass Skin, hair, and nail changes Fatigue, depression, and the blahs Dehydration Less Common but Serious Side Effects Pancreatitis and pancreatic cancer Gallstones & gallbladder disease Thyroid cancer Acute kidney injury Retinopathy, macular degeneration, and nonarteritic anterior ischemic optic neuropathy (NAION) Common GLP-1 Side Effects and How to Manage Them Most side effects show up early, often within the first few days of beginning GLP-1 treatment

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Recent randomized triple blinded crossover placebo control trial of Acetyl-L-carnitive in migraine prevention