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Initial*Possible Side Effects and Contraindications of B12: A vitamin B12 shot is safe and generally has no side effects, even in higher doses

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Doctors decide on combination therapy based on each patients needs

Since B12 is found primarily in animal products, including meat, fish, dairy, and eggs, a substantial reduction in food intake can reduce B12 consumption below optimal levels, particularly for patients who were already borderline deficient before starting treatment or whose diets lean toward plant-based foods