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This has shown promising results, namely when the apo-form of -parvalbumin is induced, leading in the case of gilthead seabream to a 50% reduction of IgE-reactivity in fish allergic patients
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The SMS gene is located on the X chromosome (Xp22.11) and is composed of 13 exons that generate two alternatively spliced mRNAs encoding SMS isoform 1 (366 amino acids) and SMS isoform 2 (313 amino acids)
Typically it is safe for all patients and has no risk of being toxic
Guidance for Industry: Bioavailability and Bioequivalence Studies Submitted in NDAs or INDs, General Considerations
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