The IDEA trial protocol used diet plus exercise for weight loss in knee OA and showed dose response
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They are deeply rooted in complex, measurable physiological disruptions, including severe mitochondrial dysfunction, rampant oxidative stress, and fundamentally impaired energy metabolism
Note the number: this is a weak dose for weight but the proven dose for the kidney, and the benefit belongs to that specific population
CNBC reports that Novo Nordisk, the Danish pharmaceutical company that makes the drug, has submitted an application for Wegovy to be approved as a treatment to reduce patients' cardiovascular disease risk.