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Ann Emerg Med

Importantly, Rybelsus (oral semaglutide) requires strict administration on an empty stomach with no more than 4 oz of water, at least 30 minutes before food or other medications

Acknowledgements This work was supported by UREKA Sarl, Immupharma Group

Similarly, the limited number of records for specific dose of GLP-1 RAs precluded an assessment of dose-response effects

As Healio previously reported, obesity drugs such as the FDA-approved tirzepatide (Zepbound, Eli Lilly) and the investigational medication retatrutide (Eli Lilly) are agents that target and activate multiple receptors, with tirzepatide being a GLP-1/glucose-dependent insulinotropic polypeptide (GIP) dual agonist and retatrutide a GLP-1/GIP/glucagon triple agonist

Further randomized controlled trials (RCTs) or large-scale database analyses are needed to confirm these observations and guide clinical recommendations