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The benefits beyond weight are real, and mostly still early Weight loss is the breakthrough, but it isn't the whole story

doi: 10.1038/s42255-023-00966-w 85 Amgen

Doses above 1000 mcg rarely accelerate onset further and instead extend duration of peak effects from 90 minutes to 23 hours

This substantial sample size provides robust statistical power and enhances the generalizability of our findings across key subgroups, such as patients with T2D, heart failure, or CKD - common indications for both GLP-1RA and SGLT2i

Later on, the FDA withdrew its approval in 2008 because of commercial reasons unrelated to its safety and efficacy