Yamauchi T et al
DSIP research extends beyond sleep physiology into areas including opioid receptor modulation, withdrawal symptom attenuation, and free radical scavenging activity
Initially, injections are given daily or every other day for a week, then weekly for 12 months, followed by monthly maintenance
The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis (Bays et al., NEJM 2025) reported 28.7% mean weight loss at 68 weeks at the 12 mg dose, plus a 75.8% reduction in WOMAC knee pain scores
Midis medical experts recommend turning to safer, evidence-based alternatives to achieve your goals: Optimize GH: Talk with a Midi clinician about sermorelin
Cooper M, Martin J, Langley K, Hamshere M, Thapar A